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KMID : 0371019900230010001
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Journal of Preventive Medicine and Public Health
1990 Volume.23 No. 1 p.1 ~ p.10
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Selenium Effect on the Frequency of SCEs Induced by Heavy Metals in Human Lymphocytes
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Koh Dai-Ha
Ki No-Suk
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Abstract
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The protective effect of sodium selenite (Na2SeO3) against the cytogenetic toxicity of heavy metals was investigated on human whole-blood cultures in relation to induction of sister chromatid exchange (SCE) in secondary metaphase chromosome.
Methylmercury chloride (CH3HgC1), cadmium chloride (CdCi2), potassium dichromate (K2Cr2O,), and sodium selenite caused to the typically dose-dependent increase in sister chromatid exchanges (SCEs) by the concentrations ranging from 0.3 pM to 10 WM.
However, the induction of sister chromatid exchanges by methylmercury chloride or cadmium chloride were inhibited by the simultaneous addition of sodium selenite 12 pM. The frequencies of SCE were decreased to the level of control .in the molar ratios as 2 : 1, 1 : 1, 1 : 2, and 1 : 4 of selenium selenite vs. methylmercury chloride, and as 1 : 1 and 1 : 2 of selenium selenite vs. cadmium chloride, while the frequencies of SCE induced by potassium dichromate were not changed by the addition of sodium selenite in culture condition.
Mitotic indices were decreased in the higher concentrations of chemicals and not significantly changed by the simultaneous addition of sodium selenite to the culture condition containing each chemicals.
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KEYWORD
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selenium, sister chromatid exchange, heavy metals
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